Antioxidant effects of ethanol seed extract of Mucuna Sloanei (Hamburger Bean) on Monosodium Glutamate intoxicated albino rats

2025-05-13T11:58:16+00:00

Some antioxidant effects of Mucuna sloanei ethanol seed extract (MSEE) were investigated in monosodium glutamate (MSG) intoxicated rats. Thirty (30) female albino rats were randomly divided into six groups (n=5) and treated once per day per os for 28 days as follows; Group A received only clean water; Group B was intoxicated with MSG at the dose of 8000 mg/kg b.w only; Group C received 400 mg/kg b.w of the extract only; Groups D-E were intoxicated with MSG (8000 mg/kg b.w) and also received different doses of the extract; 200, 400 and 800 mg/kg b.w respectively. Thereafter, blood was collected for assay of reduced glutathione GSH, superoxide dismutase (SOD) and catalase (CAT) activities, as well of malondialdehyde (MDA). The results showed that MSG reduced GSH level from 63.08±3.98 IU/L in rats given only MSEE to 37.37±2.27 IU/L. This was however reversed by MSEE in intoxicated rats at all doses, with 400 mg/kg giving a significant (P<0.05) increase in GSH of 50.25 IU/L. The extract at 800 mg/kg, significantly (P<0.05) increased SOD and CAT activities from 20.15 IU/L in MSG intoxicated rats to 25.43 IU/L, and 3.75 IU/L to 29.80 IU/L respectively. The extract also reduced the level of malondialdehyde, a marker for peroxidation, which was increased by MSG intoxication. We conclude that MSEE reverses oxidative effects of MSG in intoxicated rats.

Journal of Sustainable Agriculture and the Environment (JSAE)

Antioxidant effects of ethanol seed extract of Mucuna Sloanei (Hamburger Bean) on Monosodium Glutamate intoxicated albino rats