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The inter-relations among Africans have remained a viable “home–grown” development paradigm in the 21st Century. While assessing political and economic interaction between Nigeria and South Africa coupling with mutual benefits is the focus of the study, the economic and political relations between the two countries spur massive debates in the political economy organisations. This study analysed and discussed bilateral relations between Nigeria and South Africa, and adds value to the existing knowledge on this subject. After a qualitative analysis, it was discovered that bilateral relations between Nigeria and South Africa have been beneficial with some comparative advantages favouring South Africa than Nigeria. The study recommends improvement in infrastructural facilities, development of high human skill resources and technological advancement tilting towards Nigeria as parts of mutual benefits.
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