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Screening study of hypertension in association of ABO Blood grouping was carried out in Amaoba in Ikwuano and AmantaAmabaUgwuekeAbia State. Blood pressure monitor and anti-sera were used for the study. Out of 209 subjects from both urban and rural areas, males 102 (48.8%) and females 107 (51.2%) were used for the study. ABO blood grouping in association of hypertension was significant in male 0+ (37.0%), A+ (31.4%) in female 0+ (68.4%), A+ (26.3%) in urban area and also in rural female A+ (35%), B+ (30%) when compared to other blood groups (p<0.05). Similarly, there is non-significant association of ABO blood group of O-, A-, AB-, B- to hypertension. Body Mass Index (BMI) indicates that subjects that were overweight in male (65.38%) and female (45.45%) in both urban and rural areas were more hypertensive than those with normal weight. Questionnaire analysis shows that the causes of hypertension in the urban area were identified to be obesity 86 (39.2%) followed by stress 74 (33.7%), then hereditary 33(15.0%) and the least is no idea 11(5.0%). In the rural areas most 40(75.4%) do not have idea of cause of hypertension, 12(22.6%) attributed hypertension to witchcraft while the least number of respondent 1(1.8%) believes much consumption of salt is the cause. The management of hypertension in the urban area was identified to include maintaining of normal weight 91(33.5%), routine check of blood pressure 73(26.9%) then adhering to medication 51(18.8%) while the least(13(4.7%) has no idea of the cause of hypertension. In the rural area majority do not have idea of the management of hypertension, some agreed to adhering to medication 35(35%) and maintaining of normal weight 5(5%). Findings from this study suggests that O+, A+, and B+ were more susceptible to hypertension indicating that there is genetic association between ABO and hypertension though some blood groups are more susceptible than others. Also overweight individuals are more prone to hypertension than those with normal weight. There is therefore need for proper health education in the communities for regular screening test and management practices of hypertension to minimize or avert the risk of resultant complications
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